New research reveals that people who discontinue blockbuster slimming jabs like Wegovy and Mounjaro tend to recover reduced body mass far faster than those who halt traditional diet and exercise regimens.
Research printed in a major health publication points out that while overweight people can lose about a fifth of their body weight while using the jabs, the weight comes back at an average rate of 0.8 kg per month after stopping.
"People buying such drugs must be cognizant of the danger of quick rebound weight gain when the medication concludes," warns lead investigator Dr. Susan Jebb.
That rate of recovery suggests a return to original mass within about one and a half years.
Comparing Therapies
The study, which reviewed dozens of studies involving over 9,000 of patients, contrasted the results of these new drugs with older methods.
Scientists point out that individuals who shed pounds through dieting generally see a more gradual creep back—approximately 0.1 kg a month—after stopping.
Understanding the Rapid Regain
Experts propose the mechanism of the injections accounts for the heightened regain.
The injections mimic a body's own chemical called GLP-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than normal might result in the body to generate a reduced amount of its endogenous hormone, and may also lessen sensitivity to its actions," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this medication means appetite is no longer kept in check, making overeating far more likely."
A Lifelong Disease?
Health authorities recommend the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, due to the likelihood of relapse, the therapy is often life-long.
This view is reinforced by drug manufacturers, who say that the results "emphasize the persistent nature of excess weight," comparing it to managing diseases like diabetes.
User Experiences
Users who have discontinued the jabs describe a intense resurgence of appetite.
"It was like a trigger that goes on and you're instantly extremely hungry," said a patient.
This challenge is compounded if users have not adopted sustainable dietary or behavioural changes during treatment.
Growing Adoption
Recent estimates show that millions of people in the UK have used weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is more common among females than men.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion access the medications through private prescriptions rather than public health services.
Finally, clinicians caution that while these medications are powerful tools for shedding pounds, they are not a standalone cure and lasting health benefits likely depends on combined behavioural management.
